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Ishida K, et al

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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

Oral cyanocobalamin supplementation (typically 50150 micrograms daily) represents an appropriate option for patients with dietary deficiency without intrinsic factor deficiency or malabsorption issues

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